discoveries which had a profound effect on many areas of medicine.

对医学的许多领域都有深刻影响的一些发现。

profound disagreement.

极大的分歧。

The overwhelming feeling is just deep, profound shock and anger.

强烈地感受到的只有刻骨铭心的震惊和愤怒。

Anna's patriotism was profound.

安娜的爱国情怀是深厚的。

This is a book full of profound, original, and challenging insights.

这是一本充满高深、新颖且富有挑战性见解的书。