If you are tired, you feel that you want to rest or sleep.
Michael is tired and he has to rest after his long trip.
迈克尔累了,他在长途旅行之后不得不休息。
You can describe a part of your body as tired if it looks or feels as if you need to rest it or to sleep.
Cucumber is good for soothing tired eyes.
黄瓜对缓解眼睛疲劳很有效。
If you are tired of something, you do not want it to continue because you are bored with it or unhappy with it.
I am tired of all the speculation.
我厌烦了所有这些猜测。